This topic explores the intricate biochemical routes through which hormones are synthesized, secreted, transported, and act upon target cells. It delves into the feedback mechanisms, receptor signaling, and cross-talk between endocrine glands that regulate vital physiological processes such as growth, metabolism, reproduction, and stress response. Understanding these pathways uncovers how hormonal imbalances lead to disorders like diabetes, thyroid dysfunction, and adrenal diseases. Recent advancements also highlight the role of genetics, epigenetics, and environmental factors in modulating these hormonal networks.