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LINC02471: A Novel Diagnostic and Prognostic Biomarker Correlated with Immune Infiltration in KIRP
Research Article - Volume: 1, Issue: 1, 2026 (March)
LINC02471: A Novel Diagnostic and Prognostic Biomarker Correlated with Immune Infiltration in KIRP Download PDF

Xinyue Jiang1+, Dengwang Chen1+, Linna Wei2*, Zudi Meng3*, and Dongmei Li4*

1Department of Histology and Embryology, Zunyi Medical University, Zunyi, China 
2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xian, China
3Department of Blood Transfusion, The First People's Hospital of Guiyang, Guiyang, China
4Department of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, China

*Correspondence to: Dongmei Li, Department of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, China, E-mail:

Received: January 21, 2026; Manuscript No: JODD-26-9133; Editor Assigned: January 23, 2026; PreQc No: JODD-26-9133 (PQ); Reviewed: February 02, 2026; Revised: February 04, 2026; Manuscript No: JODD-26-9133 (R); Published: March 11, 2026

ABSTRACT

Background: Kidney renal papillary cell carcinoma (KIRP) is a histologically heterogeneous renal cancer subtype with distinct clinical behavior. While localized cases have favorable outcomes, advanced or metastatic KIRP presents significant therapeutic challenges due to limited targeted therapies and reliable biomarkers. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators in tumorigenesis and tumor immune microenvironment (TIME) modulation.

Methods: We comprehensively analyzed RNA-sequencing and clinical data from the TCGA-KIRP cohort. LINC02471 expression was evaluated using Wilcoxon tests, its diagnostic efficacy via ROC curve analysis, and prognostic value through Kaplan-Meier survival analysis with log-rank tests. Immune cell infiltration was assessed using ssGSEA and Spearman correlation. Experimental validation included qPCR expression profiling across multiple KIRP cell lines, lentivirus-mediated knockdown and overexpression, and CCK-8 proliferation assays.

Results: LINC02471 was significantly upregulated in KIRP tissues and correlated with advanced pathological stages. It demonstrated excellent diagnostic accuracy (AUC = 0.887) and was associated with improved overall survival (HR = 0.49), disease-specific survival (HR = 0.12), and progression-free interval (HR = 0.44). LINC02471 expression negatively correlated with plasmacytoid dendritic cells (R = -0.538), activated dendritic cells (R = -0.362), and natural killer cells (R = -0.360). In vitro experiments confirmed LINC02471 upregulation in KIRP cells and revealed its pro-proliferative function through gain- and loss-of-function studies.

Conclusion: Our integrated analysis identifies LINC02471 as a robust diagnostic biomarker and independent favorable prognostic indicator in KIRP. Its correlation with immune cell subsets and demonstrated proliferative role position it as a promising candidate for mechanistic studies and therapeutic development in renal papillary cell carcinoma.

Keywords: Kidney Renal Papillary Cell Carcinoma (KIRP); LINC02471; Long Non-Coding RNA; Biomarker; Prognosis; Tumor Immune Microenvironment; TCGA

Citation: Jiang X, Chen D, Wei L, Meng Z, Li D (2026). LINC02471: A Novel Diagnostic and Prognostic Biomarker Correlated with Immune Infiltration in KIRP. Oncol. Ther. Drug Dev. Vol.1 Iss.1, March (2026), pp:6-13.
Copyright: © 2026 Xinyue Jiang, Dengwang Chen, Linna Wei, Zudi Meng, Dongmei Li. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.