Maternal-Fetal Interface refers to the dynamic biological and immunological interaction between a mother and her developing fetus during pregnancy. It plays a critical role in supporting fetal growth, nutrient exchange, and immune tolerance. Research in this area helps us understand complications like preeclampsia, preterm birth, and miscarriage. The interface involves complex signaling between maternal tissues and the placenta. Studying it enhances maternal and neonatal health outcomes through improved prenatal care and interventions.