Journal of Microbiome and Gut Health

The Journal of Microbiome and Gut Health is a peer-reviewed, open-access journal dedicated to advancing scientific understanding of the human microbiome and its integral role in health, disease, and therapeutic development. The journal provides an international platform for the publication of high-quality research, innovative discoveries, and emerging interventions related to the gut microbiome and its broader systemic impact.

The journal covers a comprehensive range of topics related to microbiome science, gut physiology, and microbiome-driven therapeutics, including but not limited to:

Human Gut Microbiome Composition & Dynamics

• High-resolution profiling of gut microbial diversity, taxonomy, and functional signatures
• Microbiome shifts during aging, lifestyle changes, diet variation, stress, or infections
• Longitudinal and cross-sectional microbiome mapping across populations
• Gut microbiome interactions with host epigenetics, immune pathways, and endocrine systems

Microbiota–Host Interactions & Mechanisms

• Signaling pathways connecting gut microbes with immune responses
• Microbial metabolites influencing neural, metabolic, and inflammatory networks
• Mechanistic studies of gut-brain, gut-lung, gut-liver, and gut-skin axes
• Microbial enzymes, microbial gene regulation, and metabolomic changes

Gut Microbiome in Disease Prevention & Treatment

• Microbiome dysbiosis in chronic diseases (IBD, obesity, cancers, diabetes, autoimmune disorders)
• Microbiota-based biomarkers for disease detection and prognosis
• Microbial signatures as predictors of drug response and therapeutic resistance
• Microbiome-modulating nutritional and lifestyle interventions

Therapeutics Targeting Microbiome

• Probiotics, prebiotics, synbiotics and post-biotic formulations
• Fecal microbiota transplantation (FMT) advancements and clinical outcomes
• Engineered microbial therapeutics, next-generation probiotics, and phage-based strategies
• Dietary‐microbiome interaction studies and precision nutrition

Microbial Ecology of the Gut System

• Host-microbe co-evolution and ecological niches of the gut microbiota
• Community resilience, network interactions, microbial succession dynamics
• Metabolic cross-feeding, symbiosis, and competition mechanisms
• Environmental factors shaping microbial ecology

Microbiome Beyond Human Health

• Plant and animal gut microbiome influencing food systems and agriculture
• Microbiome in aquaculture, livestock, and zoonotic disease studies
• Gut microbes influencing environmental health and ecosystem cycles
• Microbial research linked to food processing, fermentation, and nutraceuticals

Computational, Multi-Omics & Systems-Level Studies

• Metagenomics, metatranscriptomics, metabolomics, proteomics in gut microbiome science
• AI/ML-driven predictive microbiome analytics and personalized microbiome profiling
• Network modeling, species clustering, and microbial gene pathway mapping
• Integration of host genetics with microbial systems biology

Clinical, Translational & Regulatory Advancements

• Microbiome-based clinical trial designs and health outcome validations
• Microbiome diagnostics, regulatory pathways, and safety guidelines
• Ethical considerations in microbiome manipulation, storage, and data privacy
• Public health implications, sanitation, nutrition policy, and microbiome-based interventions

Microbial Structural & Functional Profiling

• Strain-level resolution of gut microbes using next-generation sequencing
• Identification of novel microbial species, genes, metabolites, and pathways
• Gut virome, mycobiome, archaeome, protozoal diversity studies
• Advances in culturomics and microbial isolation techniques

Gut Microbiome in Immune Modulation

• Microbiome-linked immune maturation in neonates, infants, and adolescents
• Microbiome-induced immune tolerance vs. chronic inflammation
• Role of gut bacteria in autoimmune disorders (RA, psoriasis, lupus, celiac disease)
• Regulatory T-cell activation, cytokine profiles, inflammasome signaling

Microbiome & Metabolic Health

• Microbial regulation of nutrient digestion, carbohydrate metabolism, and lipid synthesis
• Microbiome contributions to metabolic syndrome, NAFLD, obesity, Type-2 diabetes
• SCFA-driven metabolic pathways (butyrate, acetate, propionate)
• Gut microbiome in metabolic therapeutics, bariatric surgery outcomes

Gut-Brain Axis & Neurological Health

• Microbiome-driven serotonergic, dopaminergic, and neuropeptide signaling
• Role in anxiety, depression, autism, Alzheimer’s and neurodevelopmental impairments
• Gut-driven regulation of brain inflammation, oxidative stress, and neurotransmission
• Microbial-neuromodulator production and neuroimmune interactions

Microbiome in Digestive Disorders

• Microbial imbalances linked to IBS, IBD, GERD, gastritis, colorectal cancer
• Microbial markers for early colorectal tumorigenesis
• Dysbiosis in antibiotic-associated diarrhea & Clostridioides difficile
• Microbiome-based therapeutic monitoring

Bioinformatics, Databases & High-Resolution Analytics

• Microbiome-specific open-source databases, data pipelines, cloud repositories
• Integration of metagenomic, phenotypic, and clinical datasets
• Microbial metabolic pathway mapping, predictive gene clustering
• Machine learning-based microbial signatures

Technological Innovations in Microbiome Science

• Microfluidic gut-on-chip and organoid-based microbiota co-culture systems
• Single-cell sequencing and spatial transcriptomics of gut tissue
• Artificial microbiota ecosystems and bioreactor-based modeling
• High-precision biosensors to detect microbial metabolites

Microbiome & Personalized Medicine

• Microbiome-centered patient stratification and therapeutic decisions
• Diagnostics based on stool microbiome profiles
• Microbiome-responsive oncology treatments (immunotherapy outcomes)
• Personalized dietary planning based on microbe-nutrient interactions

Food, Diet, and Nutraceutical Microbiology

• Traditional fermented foods as microbiome modulators
• Gut response to vegan, ketogenic, gluten-free, low-FODMAP diets
• Functional foods, dietary fibers, polyphenols, natural extracts
• Influence of artificial sweeteners, processed foods, and additives

Microbiome-Centered Public Health Innovations

• Population microbiome surveillance studies
• Microbiome-based infant nutrition and maternal health programs
• Sanitation, hygiene, antibiotic stewardship frameworks
• Epidemiological modeling of microbiome–disease burden

Regulatory Sciences, Ethics & Standardization

• Guidelines for probiotic safety, strain labeling, shelf-life verification
• Standardized microbiome sampling, storage, sequencing protocols
• Ethical considerations in microbiome data sharing
• Commercialization of microbiome-based nutraceuticals and diagnostics

The journal publishes original research articles, reviews, mini-reviews, short communications, case studies, clinical research reports, and expert perspectives that advance the understanding of gut microbial ecosystems and their therapeutic potential.

The Journal of Microbiome and Gut Health aims to foster collaboration among microbiologists, gastroenterologists, immunologists, nutrition scientists, computational biologists, clinicians, and industry innovators. By promoting scientific excellence, interdisciplinary dialogue, and global knowledge exchange, the journal strives to accelerate advancements in microbiome research and support the development of microbiome-based strategies to enhance human health and well-being.