Journal of Microbiome and Gut Health

The Journal of Microbiome and Gut Health is a peer-reviewed, open-access journal covering research on the human microbiome, gut and extra-intestinal microbial ecosystems, microbiota-host interactions, microbiome-associated diseases, diagnostics, therapeutics, nutrition, and related biological and clinical sciences.

The journal welcomes original research articles, review articles, mini-reviews, short communications, case studies, clinical research reports, expert perspectives, and other scholarly contributions relevant to microbiome and gut health research.

Human Gut Microbiome Composition & Dynamics

• High-resolution profiling of gut microbial diversity, taxonomy, and functional signatures
• Microbiome changes associated with aging, lifestyle, diet, stress, and infections
• Longitudinal and cross-sectional microbiome studies across populations
• Interactions between gut microbiota, host epigenetics, immune pathways, and endocrine systems

Human Microbiome Beyond the Gut

• Respiratory tract microbiome, including nasopharyngeal and lung microbial communities
• Microbial colonization patterns across different human body sites and life stages
• Epidemiology of commensal and opportunistic microorganisms in human microbiota
• Antimicrobial resistance within human microbial ecosystems
• Microbiota-associated infectious diseases and related public-health considerations

Microbiota–Host Interactions & Mechanisms

• Signaling pathways connecting microbes with immune responses
• Microbial metabolites influencing neurological, metabolic, and inflammatory processes
• Gut-brain, gut-lung, gut-liver, and gut-skin axis research
• Microbial enzymes, gene regulation, and metabolomic changes

Gut Microbiome in Disease Prevention & Treatment

• Microbiome dysbiosis associated with inflammatory, metabolic, autoimmune, and other chronic diseases
• Microbiota-based biomarkers for disease detection and prognosis
• Microbial signatures associated with treatment response and resistance
• Nutrition and lifestyle interventions affecting the microbiome

Therapeutics Targeting Microbiome

• Probiotics, prebiotics, synbiotics, and postbiotic formulations
• Fecal microbiota transplantation and related clinical research
• Engineered microbial therapeutics, next-generation probiotics, and phage-based approaches
• Dietary-microbiome interactions and precision nutrition

Microbial Ecology of the Gut System

• Host-microbe co-evolution and ecological niches
• Community resilience, network interactions, and microbial succession
• Metabolic cross-feeding, symbiosis, and competition
• Environmental factors influencing microbial ecology

Microbiome Beyond Human Health

• Plant and animal microbiomes relevant to food systems and agriculture
• Microbiome research in aquaculture, livestock, and zoonotic disease studies
• Microbial relationships with environmental health and ecosystem processes
• Food processing, fermentation, and nutraceutical microbiology

Computational, Multi-Omics & Systems-Level Studies

• Metagenomics, metatranscriptomics, metabolomics, and proteomics
• Artificial intelligence and machine-learning approaches in microbiome research
• Network modeling, microbial clustering, and pathway mapping
• Integration of host genetics with microbial systems biology

Clinical, Translational & Regulatory Research

• Microbiome-based clinical and translational studies
• Microbiome diagnostics, regulatory pathways, and safety considerations
• Ethical considerations in microbiome manipulation, data sharing, and privacy
• Public-health, sanitation, nutrition-policy, and microbiome intervention research

Microbial Structural & Functional Profiling

• Strain-level characterization using next-generation sequencing
• Identification of microbial species, genes, metabolites, and pathways
• Gut virome, mycobiome, archaeome, and protozoal diversity
• Culturomics and microbial isolation techniques

Gut Microbiome in Immune Modulation

• Microbiome-linked immune maturation across life stages
• Microbiome-associated immune tolerance and chronic inflammation
• Microbiome relationships with autoimmune and inflammatory disorders
• Regulatory T-cell activity, cytokine profiles, and inflammasome signaling

Microbiome & Metabolic Health

• Microbial regulation of nutrient digestion and metabolic pathways
• Microbiome relationships with metabolic syndrome, obesity, diabetes, and related conditions
• Short-chain fatty acid metabolism and signaling
• Microbiome research in metabolic interventions and bariatric care

Gut-Brain Axis & Neurological Health

• Microbial influences on serotonergic, dopaminergic, and neuropeptide signaling
• Microbiome research involving psychiatric and neurological conditions
• Gut-associated regulation of neuroinflammation and neurotransmission
• Microbial neuromodulators and neuroimmune interactions

Microbiome in Digestive Disorders

• Microbial imbalances associated with IBS, IBD, GERD, gastritis, and colorectal disease
• Microbial markers associated with colorectal tumorigenesis
• Dysbiosis associated with antibiotic-associated diarrhea and Clostridioides difficile
• Microbiome-based therapeutic monitoring

Bioinformatics, Databases & High-Resolution Analytics

• Microbiome databases, data pipelines, and computational repositories
• Integration of metagenomic, phenotypic, and clinical datasets
• Microbial metabolic pathway mapping and predictive gene clustering
• Machine-learning approaches for microbial signatures

Technological Innovations in Microbiome Science

• Microfluidic gut-on-chip and organoid-based microbiota systems
• Single-cell sequencing and spatial transcriptomics
• Artificial microbiota ecosystems and bioreactor-based models
• Biosensors for microbial metabolites and microbiome-related measurements

Microbiome & Personalized Medicine

• Microbiome-based patient stratification and therapeutic decision support
• Diagnostics based on microbiome profiles
• Microbiome research in oncology and immunotherapy
• Personalized nutrition based on microbe-nutrient interactions

Food, Diet, and Nutraceutical Microbiology

• Traditional fermented foods and microbiome interactions
• Microbiome responses to different dietary patterns
• Functional foods, dietary fibers, polyphenols, and natural extracts
• Effects of food additives and processed foods on the microbiome

Animal and Preclinical Microbiome Research

• Animal microbiome studies relevant to human health
• Preclinical evaluation of microbiome-based interventions
• Host-microbiota interactions in animal disease models
• Translational animal studies with relevance to clinical research

Microbiome-Centered Public Health

• Population microbiome surveillance
• Microbiome-related maternal and infant health research
• Sanitation, hygiene, and antibiotic stewardship
• Epidemiological studies of microbiome-associated disease burden

Regulatory Sciences, Ethics & Standardization

• Probiotic safety, strain identification, labeling, and quality considerations
• Standardized microbiome sampling, storage, and sequencing protocols
• Ethical considerations in microbiome data sharing and manipulation
• Regulatory and commercialization considerations for microbiome-based products

Through peer review and open-access dissemination, the journal supports responsible communication of microbiome research among scientists, clinicians, healthcare professionals, nutrition researchers, computational biologists, and other relevant stakeholders.