Journal of Medicinal Chemistry
Indexed In
Journal Highlights
Chiral Drug Synthesis and Stereochemistry
Covalent Inhibitors and Irreversible Drugs
Prodrug Strategies and Design
Radiopharmaceutical Chemistry
Nanotechnology in Drug Development
Chemical Biology Tools in Target Discovery
Drug Repurposing Repositioning
Drug Receptor Interactions
Ligand Based Drug Design
Structure Based Drug Design
Combinatorial Chemistry
Pharmacophores
Lipinskis Rule of Five and Drug Likeness
Isosterism and Bioisosterism
Click Chemistry in Drug Discovery
Asymmetric Synthesis in Drug Development
Biologics and Monoclonal Antibodies
RNA Based Therapeutics
Proteolysis Targeting Chimeras
Green Chemistry in Medicinal Chemistry
Chemoinformatics and Machine Learning
In Vitro and In Vivo Pharmacology
Animal Models in Drug Testing
Transporters in Drug Delivery
Neuropharmacology and Neurochemistry
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Medicinal Chemistry of Natural Products
Medicinal chemistry of natural products focuses on the discovery, design, and development of bioactive compounds derived from natural sources like plants, microbes, and marine organisms. These compounds often serve as lead structures for new drug development due to their diverse chemical scaffolds. Natural products have historically played a vital role in treating diseases such as cancer, infections, and inflammation. Advanced techniques like structure-activity relationship (SAR) studies and molecular docking are used to enhance their pharmacological profiles. Isolation and structural elucidation involve modern spectroscopic methods including NMR and MS. Synthetic modification improves efficacy, selectivity, and drug-like properties. Many FDA-approved drugs are natural product derivatives. This field bridges traditional medicine with modern drug discovery platforms.