Journal of Medicinal Chemistry
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Journal Highlights
Chiral Drug Synthesis and Stereochemistry
Covalent Inhibitors and Irreversible Drugs
Prodrug Strategies and Design
Radiopharmaceutical Chemistry
Nanotechnology in Drug Development
Chemical Biology Tools in Target Discovery
Drug Repurposing Repositioning
Drug Receptor Interactions
Ligand Based Drug Design
Structure Based Drug Design
Combinatorial Chemistry
Pharmacophores
Lipinskis Rule of Five and Drug Likeness
Isosterism and Bioisosterism
Click Chemistry in Drug Discovery
Asymmetric Synthesis in Drug Development
Biologics and Monoclonal Antibodies
RNA Based Therapeutics
Proteolysis Targeting Chimeras
Green Chemistry in Medicinal Chemistry
Chemoinformatics and Machine Learning
In Vitro and In Vivo Pharmacology
Animal Models in Drug Testing
Transporters in Drug Delivery
Neuropharmacology and Neurochemistry
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Chiral Drug Synthesis and Stereochemistry
Chiral drug synthesis and stereochemistry are critical in medicinal chemistry due to the distinct biological activities of enantiomers. Many drugs exist as chiral molecules, and often only one enantiomer exhibits the desired therapeutic effect. Stereo selective synthesis techniques, including asymmetric catalysis and chiral auxiliaries, are employed to produce specific enantiomers. The study of stereochemistry helps understand the interaction between chiral drugs and biological targets like enzymes and receptors. Regulatory agencies now emphasize the development of single-enantiomer drugs for improved safety and efficacy. Analytical techniques like chiral HPLC and circular dichroism assist in enantiomeric purity assessment. Advances in stereo selective synthesis reduce side effects and increase potency. Thus, stereochemistry plays a vital role in modern drug design and development.