Lipinski's Rule of Five offers criteria for assessing the drug-likeness of compounds, particularly in relation to oral bioavailability. The rules state that good drug candidates typically have ≤5 hydrogen bond donors, ≤10 hydrogen bond acceptors, molecular weight ≤500 Da, and logP ≤5. Violating more than one rule suggests poor absorption or permeation. These criteria help screen compounds early in drug discovery.