Journal of Medicinal Chemistry
Indexed In
Journal Highlights
Chiral Drug Synthesis and Stereochemistry
Covalent Inhibitors and Irreversible Drugs
Prodrug Strategies and Design
Radiopharmaceutical Chemistry
Nanotechnology in Drug Development
Chemical Biology Tools in Target Discovery
Drug Repurposing Repositioning
Drug Receptor Interactions
Ligand Based Drug Design
Structure Based Drug Design
Combinatorial Chemistry
Pharmacophores
Lipinskis Rule of Five and Drug Likeness
Isosterism and Bioisosterism
Click Chemistry in Drug Discovery
Asymmetric Synthesis in Drug Development
Biologics and Monoclonal Antibodies
RNA Based Therapeutics
Proteolysis Targeting Chimeras
Green Chemistry in Medicinal Chemistry
Chemoinformatics and Machine Learning
In Vitro and In Vivo Pharmacology
Animal Models in Drug Testing
Transporters in Drug Delivery
Neuropharmacology and Neurochemistry
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Chemical Biology Tools in Target Discovery
Chemical biology tools play a crucial role in target discovery by enabling the identification and validation of biological molecules involved in disease pathways. Small molecule probes are used to modulate protein function and study cellular responses. Activity-based protein profiling (ABPP) allows selective labelling of active enzymes within complex proteomes. Click chemistry facilitates biorthogonal labelling and visualization of biomolecular interactions. CRISPR-Cas9 and RNAi technologies are combined with chemical tools for functional genomics studies. Photo affinity labelling helps identify drug-binding targets through covalent capture upon light activation. These tools bridge chemistry and biology, accelerating the understanding of disease mechanisms. Ultimately, they guide the development of more effective and selective therapeutics.