Journal of Medicinal Chemistry
Indexed In
Journal Highlights
Chiral Drug Synthesis and Stereochemistry
Covalent Inhibitors and Irreversible Drugs
Prodrug Strategies and Design
Radiopharmaceutical Chemistry
Nanotechnology in Drug Development
Chemical Biology Tools in Target Discovery
Drug Repurposing Repositioning
Drug Receptor Interactions
Ligand Based Drug Design
Structure Based Drug Design
Combinatorial Chemistry
Pharmacophores
Lipinskis Rule of Five and Drug Likeness
Isosterism and Bioisosterism
Click Chemistry in Drug Discovery
Asymmetric Synthesis in Drug Development
Biologics and Monoclonal Antibodies
RNA Based Therapeutics
Proteolysis Targeting Chimeras
Green Chemistry in Medicinal Chemistry
Chemoinformatics and Machine Learning
In Vitro and In Vivo Pharmacology
Animal Models in Drug Testing
Transporters in Drug Delivery
Neuropharmacology and Neurochemistry
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Drug Repurposing Repositioning
Drug repurposing, or repositioning, involves identifying new therapeutic uses for existing or previously failed drugs. This strategy significantly reduces the time, cost, and risk associated with drug development. Repurposed drugs already have established safety profiles, allowing for faster progression to clinical trials. Computational approaches, including AI and bioinformatics, aid in predicting novel drug-disease associations. Examples include sildenafil (originally for angina, now used for erectile dysfunction) and thalidomide (repurposed for multiple myeloma). Drug repurposing is especially valuable during health emergencies, such as the COVID-19 pandemic. It can uncover hidden therapeutic potentials and offer new treatments for rare or neglected diseases. This approach enhances innovation by leveraging existing pharmacological knowledge.