Ethical, regulatory, and translational issues play a critical role in stem cell research and its clinical applications. Ethical concerns often revolve around the source of stem cells, particularly embryonic stem cells, and informed consent from donors. Regulatory frameworks ensure the safety, efficacy, and quality of stem cell-based therapies before human use. Translational challenges include bridging the gap between laboratory findings and real-world clinical treatments. Navigating these issues is essential for responsible innovation and public trust in regenerative medicine.