Stem cell gene editing, particularly using CRISPR technology, has opened new frontiers in precision medicine. CRISPR allows for targeted modifications in stem cell DNA, enabling the correction of genetic defects at the source. This approach holds promise for treating inherited disorders, cancers, and other diseases. Combining gene editing with stem cells enhances the development of personalized therapies and disease models. Ongoing research focuses on improving safety, accuracy, and ethical oversight of these powerful tools.