Biomaterials and scaffold integration with stem cells have revolutionized regenerative medicine by providing structural support and biological cues for cell growth and tissue formation. Recent advances focus on designing biocompatible, biodegradable scaffolds that mimic the natural extracellular matrix. These scaffolds enhance stem cell differentiation, proliferation, and integration into damaged tissues. Smart biomaterials with controlled release of growth factors further optimize healing. This synergy holds immense promise for treating complex injuries and degenerative diseases.