Journal of Stem cell Research and Therapy

Short Biography (Dr. Seiji Ogawa, M.D., Ph.D.) Dr. Seiji Ogawa, M.D., Ph.D., is an Associate Professor at the Center for Advanced Reproductive Medicine, Fujita Health University (Haneda Clinic, Tokyo, Japan). He is a board-certified obstetrician and gynecologist specializing in reproductive and regenerative medicine. Dr. Ogawa earned his Ph.D. in Obstetrics and Gynecology from Keio University School of Medicine, where he investigated molecular mechanisms of early embryonic development and genomic stability. His current clinical and research interests focus on assisted reproductive technologies (ART), oxidative stress and male infertility, and the application of regenerative medicine to infertility treatment. He has conducted pioneering clinical studies using platelet-rich plasma (PRP) and menstrual blood-derived mesenchymal stem cells (Men-MSCs) for ovarian rejuvenation and endometrial regeneration being the first in Japan to implement intraovarian Men-MSC therapy for infertility in 2023.

Dr. Ogawa is the recipient of the 2020 Academic Encouragement Award from the Japan Society for Reproductive Medicine and serves as a council member of several reproductive medicine societies in Japan. He continues to promote translational research bridging basic science and clinical innovation to improve reproductive outcomes for patients.

• Assisted Reproductive Technologies (ART)
• Preimplantation embryonic development
• Regenerative medicine in infertility
• Clinical trials for improving male fertility via antioxidant supplements

• Clinical Innovation / Regenerative Therapies
  • Implemented PRP (platelet-rich plasma) therapy in patients with thin endometrium and repeated implantation failure
  • Developed and applied menstrual blood–derived mesenchymal stem cell therapy (intraovarian & intrauterine) for infertile patients
  • Led clinical research trials on nutritional / antioxidant supplementation in male fertility

• Society & Meeting Leadership
  • Council Member, Japan Society for Fertilization and Implantation
  • Council Member, Japan Laser Reproduction Society
  • Organized the 16th Annual Meeting of the Japan Laser Reproduction Society (2022)
  • Served as Secretariat for the 41st Annual Meeting of the Japan Society for Fertilization and Implantation (2023)

• Honors, Grants & Awards
  • Japan Society for Reproductive Medicine Academic Encouragement Award (2020)
  • Grant-in-Aid for Young Scientists (B) (2011–2013, and 2025–)
  • Co-Investigator, Grant-in-Aid for Scientific Research (B) (2010–2012)

• Licenses & Certification
  • Physician’s license, Japan (#444848)
  • Board certified: Obstetrics & Gynecology, Women’s Medicine, Reproductive Medicine, Anti-Aging Medicine

• Hiromi Izawa, Charlie Xiang, Seiji Ogawa, Ichiro Hisanaga, Takayuki Yoshimoto. “Amelioration of female menopausal syndrome by intravenous administration of autologous menstrual blood-derived stem cells.” Regenerative Therapy, 2025 (Vol. 29), pp. 192–201.

• Seiji Ogawa, Kuniaki Ota, Kaori Nishizawa, Masumi Shinagawa, Mikiko Katagiri, Hiroyuki Kikuchi, Hideyuki Kobayashi, Toshifumi Takahashi & Hiroaki Yoshida. “Micronutrient Antioxidants for Men (Menevit®) Improve Sperm Function by Reducing Oxidative Stress, Resulting in Improved ART Outcomes.” Antioxidants, 2024, 13, 635.

• Seiji Ogawa, Kuniaki Ota, Toshifumi Takahashi, Hiroaki Yoshida. “Impact of Homocysteine as a Preconceptional Screening Factor for In Vitro Fertilization and Prevention of Miscarriage with Folic Acid Supplementation following Frozen-Thawed Embryo Transfer: A Hospital-Based Retrospective Cohort Study.” Nutrients, 2023; 15: 3730.

• Kamijo, T., Hamatani, T., Sasaki, H., Suzuki, H., Abe, A., Inoue, O., Iwai, M., Ogawa, S., Odawara, K., Tanaka, K., Mikashima, M., Suzuki, M., Miyado, K., Matoba, R., Odawara, Y., Tanaka, M. “MicroRNAs secreted by human preimplantation embryos and IVF outcome.” Reproductive Biology and Endocrinology, 2022; 20(1):130.

• Seiji Ogawa, Mitsutoshi Yamada, Akihiro Nakamura, Tohru Sugawara, Akari Nakamura, Shoko Miyajima, Yuichirou Harada, Reina Ooka, Ryuichiro Okawa, Jun Miyauchi, Hideki Tsumura, Yasunori Yoshimura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, Akihiro Umezawa & Toshio Hamatani. “Zscan5b deficiency impairs DNA damage response and causes chromosomal aberrations during mitosis.” Stem Cell Reports, 2019; 12(6): 1366–1379.

• Sasaki H, Hamatani T, Kamijo S, Iwai M, Kobanawa M, Ogawa S, Miyado K, Tanaka M. “Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence.” Frontiers in Endocrinology, 2019.

• Inoue O, Hamatani T, Susumu N, Yamagami W, Ogawa S, Takemoto T, Hirasawa A, Banno K, Kuji N, Tanaka M, Aoki D. “Factors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia.” Reproductive Biology and Endocrinology, 2016;14:2.

• Sugawara K, Hamatani T, Yamada M, Ogawa S, Kamijo S, Kuji N, Akutsu H, Miyado K, Yoshimura Y, Umezawa A. “Derivation of human decidua-like cells from amnion and menstrual blood.” Scientific Reports, 2014;4:4599.

• Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarín JJ, Kuji N, Umezawa A, Yoshimura Y. “Age-associated telomere shortening in mouse oocytes.” Reproductive Biology and Endocrinology, 2013;11:108.

• Yamada M, Takanashi K, Hamatani T, Hirayama A, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Shinoda K, Soga T, Umezawa A, Kuji N, Yoshimura Y, Tomita M. “A medium-chain fatty acid as an alternative energy source in mouse preimplantation development.” Scientific Reports, 2012; 2:930.

• Kawaguchi M, Banno K, Yanokura M, Kobayashi Y, Kishimi A, Ogawa S, Kisu I, Nomura H, Hirasawa A, Susumu N, Aoki D. “Analysis of candidate target genes for mononucleotide repeat mutation in microsatellite instability-high (MSI-H) endometrial cancer.” International Journal of Oncology, 2009;35(5):977–982.