Stem Cells, Biomaterials and Tissue Engineering

Dr. Jefferson Luiz da Silva is a Brazilian immunologist and parasitologist whose research focuses on the interactions between hormones, the immune system, the intestinal microbiota, and inflammation. He earned his Ph.D. in Pharmacy and M.Sc. in Applied Immunology from the University of São Paulo (USP) and currently serves as a Collaborating Professor at the Institute of Biosciences, São Paulo State University (UNESP), Botucatu. His studies explore endocrine–immune regulation, mucosal immunity, and host–pathogen interactions, with applications in parasitic diseases and inflammatory disorders. Dr. Silva has authored several peer-reviewed articles and contributes to teaching and mentorship in immunology and microbiology.

• Cellular and mucosal immunology
• Hormonal regulation of immune responses
• Microbiota–host immune interactions
• Parasitic infections

• Teaching roles in postgraduate and undergraduate courses (e.g. in Microbiology, Immunology, mucosal immunity)
• Laboratory supervision and technical work in experimental models (inflammation, parasitic infection)
• Participation as monitor, tutor, or volunteer assistant in academic and lab courses (during master’s and undergraduate)
• Engagement in short courses, workshops, and technical training related to immunology, molecular biology, histology, animal models, etc.
• Presentations in national and international academic events (symposia, congresses, workshops)
• Participation in research projects (individually and as collaborator) across immunology, parasitology, microbiota, and hormone-immune crosslinks

1. Ferreira Junior, A. S.; da Silva, B. F. R.; Da Silva, J. L. et al. “Unraveling the Intestinal Microbiota Conundrum in Allogeneic Hematopoietic Stem Cell Transplantation: Fingerprints, Clinical Implications and Future Directions.” Journal of Clinical Medicine (2025).
2. Pinzan, Camila Figueiredo; Valero, Clara; de Castro, Patricia Alves; Da Silva, Jefferson Luiz; et al. “Aspergillus fumigatus conidial surface-associated proteome reveals factors for fungal evasion and host immunity modulation.” Nature Microbiology (2024).
3. Silva, Jefferson Luiz; Pinzan, Camila F.; Duartte, Andressa; et al. “Testosterone leads to Trypanosoma cruzi glycoprotein synthesis and increased of inflammatory mediators in bone marrow-derived macrophages.” Experimental Parasitology (2024).
4. Goulart, Amanda; Anchieta, Naira Ferreira; Sampaio, Pedro Alexandre; Brazão, Vânia; Silva, Jefferson Luiz da; et al. “Cafeteria diet-induced obesity remodels immune response in acute Trypanosoma cruzi infection.” Immunobiology (2023).
5. Da Silva, Jefferson Luiz; Barbosa, Lia Vezenfard; Pinzan, Camila F.; Nardini, Viviani; Brigo, Irislene Simões; et al. “The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation.” Microorganisms (2023).
6. Sampaio, Pedro Alexandre; Goulart, Amanda; Brazão, Vânia; Anchieta, Naira Ferreira; Silva, Jefferson Luiz; et al. “Hypothyroidism impairs the host immune response during the acute phase of Chagas disease.” Immunobiology (2020).
7. Oliveira, R. G.; Araujo, A. J. B.; Teixeira, A. C. M.; Domingues, C. M.; Vilela, D. A.; Messias, D. Q.; Silva, J. L.; et al. “O estudo do ‘gênero’ na escola.” Horizonte Científico (Uberlândia), 2016.