Journal menu

open access
Journal of Innovative Dental Sciences

+44 7897 072181
Effects of Naturally Collagen-derived Membranes from Bovine Pericardium and Dermis in Guided Bone Regeneration: An animal study in a cranial bone defect model
Research Article - Volume: 1, Issue: 2, 2025 (September)
Effects of Naturally Collagen-derived Membranes from Bovine Pericardium and Dermis in Guided Bone Regeneration: An animal study in a cranial bone defect model Download PDF

Yanqi Chen1, Antian Xu2, Siyuan Wang2, Xiaoyu Chen2, Yangbo Xu2 and Fuming He2*
1Department of Pediatrics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Disease of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China 310006.

2Department of Prosthodontics, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Disease of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China 310006.

*Correspondence to: Fuming He, Department of Prosthodontics, Stomatology Hospital, Zhejiang University School of Medicine, Hangzhou, China.. Tel: +86 13516817697, E-Mail:

Received: June 26, 2025; Manuscript No: JDSS-25-5373; Editor Assigned: June 30, 2025; PreQc No: JDSS-25-5373(PQ); Reviewed: July 08, 2025; Revised: July 15, 2025; Manuscript No: JDSS-25-5373(R); Published: September 04, 2025

ABSTRACT

Background/Purpose: Naturally derived collagen membranes have garnered significant attention in GBR. However, scarce knowledge exists about the consequences of the usage of different tissue sources. The objective of this study was to explore tissue integration patterns of xenogeneic collage membranes from different animal species and tissues.

Material and Methods: The materials derived from Bovine Pericardium (BP) and Dermis (BD) were characterized and compared to the Porcine-sourced Dermis membrane (PD). Histological, immunohistochemical and bone histomorphometrical methodologies were conducted at six time points in a cranial bone defect model using SD rats.

Results: Characteristics analysis revealed that all membranes had a bilayer structure, with the BP membranes exhibiting a highest degree of purity in type I collagen. Histological results showed that both the BP and PD membranes initially displayed mild inflammation and vascularization within the bed implantation. The BP membranes demonstrated partial degradation with a stable rate over 16 weeks, whereas the PD membrane experienced nearly complete biodegradation. In term of bone regeneration and soft tissue healing, the BP membranes yielded outcomes comparable to those of the PD membranes. In contrast, the BD membranes provoked a strong foreign body reaction, which impeded tissue integration and osteogenic performance, despite exhibiting a high vessel density.

Conclusions: An exuberant vascularization may not contribute to its tissue regeneration function. The BP membrane demonstrated optimal degradation behavior and superior barrier function, showing comparable results in both bone regeneration and soft tissue healing when compared to the PD membrane, which may serve as an ideal GBR membrane. Keywords: collagen membrane; guided bone regeneration; degradation; tissue source, bovine-sourced pericardium

Keywords: collagen membrane; guided bone regeneration; degradation; tissue source; bovine-sourced; pericardium.

Citation: Fuming He (2025). Effects of Naturally Collagen-derived Membranes from Bovine Pericardium and Dermis in Guided Bone Regeneration: An animal study in a cranial bone defect model. J Innov Dent Sci. Vol.1 Iss.2, September (2025), pp:9-18.
Copyright: © 2025 Fuming He. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.