Everything in dermatology starts with knowing how the skin works its structure, how it protects us, how it reacts to threats, why it changes color, what happens as we age, and how it heals. This section covers all of that: skin biology, the immune system’s role, inflammation, pigmentation, aging, and wound repair. The journal cares a lot about research that actually connects the lab to the clinic. It looks for studies that turn discoveries about skin cells or molecules into real-world tools like new ways to diagnose, treat, or prevent skin problems. This approach builds a solid scientific base for both clinical and cosmetic dermatology and pushes the field forward with research rooted in real biology.