Quantum and High-Energy Computational Physics bring together advanced algorithms, machine learning, and high-performance computing to explore the most fundamental laws governing matter, energy, and the universe. Deep learning accelerates the discovery of novel quantum states, helps reconstruct particle collision events, and models the behavior of strongly correlated systems. Quantum simulation platforms replicate subatomic interactions and exotic phases of matter that are impossible to observe directly. High-energy physics experiments such as particle accelerators generate massive datasets, requiring intelligent filtering, anomaly detection, and pattern recognition. Quantum algorithms promise breakthroughs in solving many-body problems, optimization, and quantum chemistry. Interdisciplinary research merges physics, computer science, applied mathematics, and engineering. Digital twins of astrophysical events model phenomena like black hole mergers, cosmic radiation, and dark matter distributions. Robust computational pipelines support global scientific collaborations. The field drives the future of energy research, materials innovation, cryptography, and fundamental cosmology by unlocking deeper understanding of nature’s building blocks.