Integrative and Cross-Disciplinary Frameworks focus on uniting diverse fields of knowledge, methodologies, and computational paradigms to solve complex problems that cannot be addressed by any single discipline. These frameworks act as connective tissue between sciences, engineering, humanities, and creative practices. Intelligent computing plays a central role by enabling data fusion, knowledge integration, and multi-scale modelling across domains such as biology, climate science, economics, sociology, and technology. Cross-disciplinary teams use shared conceptual foundations-systems thinking, complexity science, network theory, and computational modelling-to develop harmonized approaches. Interoperable platforms, ontologies, and knowledge graphs support seamless collaboration, allowing researchers to integrate heterogeneous data, theories, and tools. Education and research programs built around interdisciplinary methodology accelerate innovation and cultivate adaptable thinkers. Ethical, cultural, and societal perspectives are embedded within these frameworks to ensure responsible and inclusive technological advancement. By bridging disciplinary boundaries, integrative frameworks generate holistic insights, catalyze transformative innovation, and foster solutions to global-scale challenges such as sustainability, health equity, and digital governance. They form the backbone of next-generation research ecosystems where intelligent computing enables truly collaborative discovery.